Artificial bioconjugates with naturally occurring linkages: the use of phosphodiester

• Takao Shoji,
• Hiroki Fukutomi,
• Yohei Okada and
• Kazuhiro Chiba

Beilstein J. Org. Chem. 2018, 14, 1946–1955, doi:10.3762/bjoc.14.169

• directly conjugated. It should be noted that there is no need to pre-install artificial functional groups and undesired and unpredictable perturbations possibly caused by bioconjugation can be minimized. Keywords: alkyl chain soluble supports; artificial bioconjugates; naturally occurring linkages; 5

• linkage. Described herein is a simple and straightforward access to artificial bioconjugates with naturally occurring linkages. Results and Discussion The present work began with the optimization of the reaction conditions for the activation of the 5’-terminus, more specifically, 5’-phosphitylation [74